The research also shows that upon differentiation, mouse ES cells adopt replication characteristics similar to those of non-pluripotent cells. Furthermore, some features of DNA replication observed in ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...