The DNA damage-activated protein kinase Chk1 is known to undergo auto-phosphorylation, however the sites and functional significance of this modification remain poorly understood. We have identified ...

Many cancer-driving mutations disable a key checkpoint in the cell’s cycle between growth and division, resulting in unchecked activity of the E2F family of transcription factor proteins. A set of ...

New research from Dana-Farber Cancer Institute shows that a new class of drug results in cell death in cancers, such as small cell lung cancer, with a disabled quality control cell cycle checkpoint ...