Polyamines are small polycationic molecules—principally putrescine, spermidine and spermine—ubiquitous in all living cells. Their biosynthesis begins with ornithine decarboxylation to form putrescine, ...

Researchers discovered that declining levels of phosphatidylcholine may be a major cause of age-related mitochondrial ...

Mitochondria are highly dynamic organelles that undergo continual cycles of fission and fusion, orchestrating their shape, distribution and functional capacity within the cell. These dynamic ...

Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in which aging cells change how they function—is associated with human brain ...

Single-cell analysis is a ubiquitous laboratory technique that allows researchers to probe the myriad biomolecular states of cells. Single-cell assays can reveal gene and protein expression patterns, ...

When oil is dropped in water, the oil droplets stay separate. Cells can also use a system like this to separate or gather materials, encouraging various reactions and processes to occur. Scientists ...

In the rapidly evolving field of drug discovery, single-cell analysis has become an invaluable tool for understanding cellular heterogeneity and molecular pathways. However, traditional single-cell ...

A faulty ion channel function is a consistent biological feature of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), providing long-awaited validation for hundreds of thousands of ...

Single-cell biology has transformed how we decode cellular heterogeneity, but a new frontier is emerging: understanding what individual cells do, not just what they express. The ability to observe ...

* Reeve-Irvine Research Center, and Departments of Anatomy/Neurobiology and Neurobiology and Behavior, College of Medicine, University of California, Irvine, CA 92697; and ‡ Department of Neuroscience ...

Similar to a small cut that heals itself after a short time, individual cells in our body suffer "wounds" in their protective layer, the cell membrane, every day and have to repair them again.

Resurrection beyond cellular disintegration is simply impossible. However, when a person dies, cell death itself isn’t instant. Researchers are taking advantage of a timed window during which they can ...