The complement system, a proteolytic cascade within innate immunity, is tightly regulated during healthy gestation to support implantation, placental development and parturition while preventing ...

Pore-forming toxins (PFTs) constitute a diverse class of proteins that permeabilise lipid bilayers, serving roles in bacterial virulence, immune defence and intercellular signalling. They encompass ...

TSP-1 reduced C3 and C5 cleavage and formation of the membrane attack complex, attenuating complement-mediated injury in AAV models. Complement activation is a relevant driver in the pathomechanisms ...