The complement system in teleost fish constitutes a cornerstone of innate defence, integrating classical, lectin and alternative activation routes to eliminate pathogens and shape inflammatory ...

The complement cascade, a cornerstone of innate immunity, has been increasingly recognised for its non-canonical role in sculpting neural circuits through synaptic pruning. Central to this process is ...

The complement system is an important part of the innate immune system that helps fight infection, heal injury and remove our dead cells. Antibodies, which are proteins produced by our immune cells, ...

Louse-borne relapsing fever is an acute bacterial infection that triggers recurring episodes of high fever. It is caused by ...

Researchers have discovered that SARS-CoV-2 hijacks three important host proteins that dampen the activity of the complement system, a key component of early antiviral immunity. This significantly ...

This article was published in Scientific American’s former blog network and reflects the views of the author, not necessarily those of Scientific American The very first line of defence against any ...

Among people with sickle cell disease—an inherited blood disorder—acute chest syndrome (ACS) is the leading cause of death. The condition is the result of red blood cells becoming stiff, sticky, and ...

Complement 3 glomerulopathy (C3G) is a rare kidney disease that affects your body’s innate immune system (complement system). Complement 3 glomerulopathy (C3G) is a kidney disease that’s caused by ...