Integrin αIIbβ3 is the principal adhesion receptor on platelets and serves as a fulcrum for bidirectional signal transduction that underpins haemostasis and thrombosis. In resting platelets, αIIbβ3 ...

Integrins are heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix and engage bidirectional signalling across the plasma membrane. Activation is controlled by ...