The schematic illustrates the comprehensive pipeline for Mendelian randomization analysis, starting with multi-omics data inputs from GWAS, eQTL, and pQTL studies, sourced from major databases such as ...

Mendelian randomization (MR) has emerged as a robust approach to disentangle causal relationships between gut microbial features and human health outcomes. By using genetic variants associated with ...

Traditional epidemiological studies have identified numerous potential risk factors, but observational studies have struggled to establish causal links due to confounding factors and reverse causation ...