Distal mutations, though far from the active site, enhance Kemp eliminase catalysis by tuning conformational dynamics that facilitate substrate binding and product release, thereby promoting the full ...

This fully updated volume explores a wide array of new and state-of-the-art tools and resources for protein function prediction. Beginning with in-depth overviews of essential underlying computational ...

RNA therapeutics have emerged as one of the most promising new classes of medicines. Eight small interfering RNA (siRNA) ...

What Are Proteoforms and Why Do They Matter? For decades, scientists assumed that each gene produces just one stable protein. Modern proteomic investigations suggest otherwise. Recent studies have ...

Overview of protein engineering strategies. Directed evolution mimics natural selection in the laboratory through iterative rounds of mutagenesis and screening. Rational design uses structural and ...

In addition to exporting materials out of the nucleus, the protein, called Exportin-1 (also called Xpo1 or Crm1), seems to play a role in promoting gene transcription, the process that creates RNA ...

Designed proteins are anticipated to have groundbreaking impact on a range of issues from treating disease to tackling environmental problems. With a DKK 700 million grant from the Novo Nordisk ...