The authors established a useful syndetome differentiation protocol from human induced pluripotent stem cells, guided by single-cell transcriptomic analysis. Their findings could significantly impact ...

Vascular Health Unit, Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Québec, Canada (J.H.B., H.P.Q., K.G., I.G., H.Z., S.S.D ...

Cells are the fundamental unit of life. To better understand their roles at the organismal level, cell types are differentiated through structural and functional characteristics. In neuroscience, this ...

Chimeric antigen receptor T cell (CAR-T) therapy is considered one of the landmark achievements of modern medicine. The therapy involves harvesting a patient’s own immune cells, genetically ...

Spatial transcriptomics is revolutionizing the study of tissue architecture, cellular states, and tumor-immune interactions in clinical specimens. This presentation introduces the principles and ...

Single-cell transcriptomics has revolutionised our understanding of the cellular complexity underlying neurodegenerative disorders by enabling the high-resolution profiling of individual brain cells.

Oregon Health & Science University researchers have developed a first-of-its-kind method to predict cancer patient survival using advanced molecular data from individual cells. Survival analysis is ...

The biological connection between a pregnant woman and her developing baby—the human maternal–fetal interface—is a specialized, transient organ composed of uterine cells from the mother and fetal ...

Bulk RNA sequencing has advanced transcriptomic analysis across diverse biological systems, but averaging gene expression across cell populations can obscure important cellular differences.

Atherosclerosis, a chronic inflammatory arterial disease, involves complex interactions among diverse immune cells. Although single-cell RNA sequencing (scRNA-seq) has revealed cellular heterogeneity ...