Abstract: Spatial transcriptomics has revolutionized the ability to investigate transcriptional patterns within tissue morphology. However, many ST clustering pipelines operate on a single preselected ...

Trends in liver metastases at diagnosis among young adults with colorectal cancer: A SEER-based analysis, 2010–2022. Genotype-directed targeted therapy combined with HAIC and tislelizumab for ...

A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the ...

A brightly colored image composed of dots that are each one of many colors. At the center of the image is a yellow-and-pink fishhook shape with clusters of green dots and clusters of blue dots around ...

Abstract: Spatial transcriptomics technologies have enabled comprehensive measurements of gene expression profiles while retaining spatial information, with most platforms also providing matched ...

Spatial EcoTyper is a versatile framework for identifying spatially distinct multicellular communities, termed spatial ecotypes, from single-cell spatial transcriptomics data. In addition, it provides ...

Spatial transcriptomics is revolutionizing the study of tissue architecture, cellular states, and tumor-immune interactions in clinical specimens. This presentation introduces the principles and ...

Cancer Res (2026) 86 (7_Supplement): 1470. Three-dimensional spatial transcriptomics (ST) is essential for characterizing tumor-microenvironment (TME) heterogeneity but profiling every serial section ...

Cancer Res (2026) 86 (7_Supplement): 1442. Tumor purity, defined as the proportion of malignant cells within a tumor region, is a critical factor in cancer research and clinical practice. Accurate ...

Spatial biology is a rapidly advancing discipline that examines biological molecules (such as DNA, RNA, and proteins) within their native locations in tissues. This approach offers critical insight ...

Tumors contain many different types of cells organized in complex spatial patterns that can influence how the disease progresses. Because of this, it is hard to predict how a tumor will develop and ...

Although containing more neurons than the rest of the brain regions combined, the cerebellum remains understudied in human development compared to the cerebral cortex. Consequently, much of our ...